If an application is run without administrative privileges, Vista restricts it from writing to the HKEY_LOCAL_MACHINE subtree in the registry, the Program Files directory, and the Windows directory. Instead, changes are written to a writable area in the registry and to the user’s local directory. This is referred to as virtualization. To avoid the issues that would result from this behavior, on Vista, you must start PowerBuilder with administrative privileges by right clicking pb110.exe in the Start menu or Explorer and selecting Run As Administrator from its pop-up menu.
You must also run PowerBuilder tools, such as the Runtime Packager, with administrative privileges. [CR 475612, CR 480682]